Article
Vascular organoid model of Hutchinson-Gilford progeria syndrome uncovers repression of the SRF pathway in premature aging.
Developmental cell - 11 Mar 2026
Sun Xiaoyan, Che Shanshan, Wang Hengchao, Fan Yanling, Ding Yingjie, Tan Ansheng, Yang Kuan, Hu Jianli, Zhang Yixin, Ma Miyang, Hu Jinghao, Sun Shuhui, Ma Shuai, Wang Si, Izpisua Belmonte Juan Carlos, Qu Jing, Zhang Weiqi, Liu Guang-Hui
Abstract excerpt
Vascular aging is a key driver of cardiovascular disease, yet models capturing its complexity in humans are lacking. Hutchinson-Gilford progeria syndrome (HGPS), a premature aging disorder caused by the LMNA mutation, provides a model to study accelerated vascular decline. Here, we developed a blood vessel organoid (BVO) model from HGPS-mutant human embryonic stem cells (hESCs). These BVOs model HGPS vascular...
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