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Article

The longevity-associated BPIFB4 gene supports cardiac function and vascularization in ageing cardiomyopathy.

Cardiovascular research - 4 Jul 2023

Cattaneo Monica, Beltrami Antonio P, Thomas Anita C, Spinetti Gaia, Alvino Valeria Vincenza, Avolio Elisa, Veneziano Claudia, Rolle Irene Giulia, Sponga Sandro, Sangalli Elena, Maciag Anna, Dal Piaz Fabrizio, Vecchione Carmine, Alenezi Aishah, Paisey Stephen, Puca Annibale A, Madeddu Paolo

Abstract excerpt

AIMS: The ageing heart naturally incurs a progressive decline in function and perfusion that available treatments cannot halt. However, some exceptional individuals maintain good health until the very late stage of their life due to favourable gene-environment interaction. We have previously shown that carriers of a longevity-associated variant (LAV) of the BPIFB4 gene enjoy prolonged health spans and lesser...

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Identifiers

PMID: 36635236
DOI: 10.1093/cvr/cvad008
PMCID: PMC10318395

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