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Article

Transcription factor EB regulates cardiovascular homeostasis

1 Jan 2021

Abstract excerpt

Cardiovascular diseases (CVDs) are the leading cause of death and a major cause of disability globally. Transcription factor EB (TFEB), as a member of the microphthalmia transcription factor (MITF) family, has been demonstrated to be a master regulator of autophagy and lysosomal biogenesis. Emerging studies suggest that TFEB regulates homeostasis in the cardiovascular system and shows beneficial effects on CVDs,...

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PMID: 33418500
DOI: 10.1016/j.ebiom.2020.103207

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