Article

Does Localisation of BPIFB4 Support Its Proposed Function in Extending Healthy Longevity?

2025-12-30

Abstract excerpt

In 2015 a polymorphic variant of Bactericidal/permeability-increasing protein (BPI) Fold containing Family B Member 4 (BPIFB4) was genetically associated with longevity. Following on from this intriguing observation, a literature has developed that suggests that this poorly characterised secreted protein, plays a pleiotropic role in maintaining human health and extending lifespan. In this article we briefly review...

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Literature Corpus work: 73f4c518-1fa6-55e7-a051-eef82d3ed3ff
DOI: 10.20944/preprints202511.1647.v2

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