A rare genetic variant of BPIFB4 predisposes to high blood pressure via impairment of nitric oxide signaling.

doi:10.1038/s41598-017-10341-x

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Article

A rare genetic variant of BPIFB4 predisposes to high blood pressure via impairment of nitric oxide signaling.

Scientific reports - 29 Aug 2017

Vecchione Carmine, Villa Francesco, Carrizzo Albino, Spinelli Chiara Carmela, Damato Antonio, Ambrosio Mariateresa, Ferrario Anna, Madonna Michele, Uccellatore Annachiara, Lupini Silvia, Maciag Anna, Ryskalin Larisa, Milanesi Luciano, Frati Giacomo, Sciarretta Sebastiano, Bellazzi Riccardo, Genovese Stefano, Ceriello Antonio, Auricchio Alberto, Malovini Alberto, Puca Annibale Alessandro

Abstract excerpt

BPIFB4 is associated with exceptional longevity: four single-nucleotide polymorphisms distinguish the wild-type form from a longevity-associated variant conferring positive effects on blood pressure. The effect of a rare variant (RV; allele frequency, 4%) on blood pressure is unknown. Here, we show that overexpression of RV-BPIFB4 in ex-vivo mouse vessels impairs phosphorylation of endothelial nitric oxide...

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Identifiers

PMID: 28852218
DOI: 10.1038/s41598-017-10341-x
PMCID: PMC5574984

Genes

BPIFB4

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