Article

Does Localisation of BPIFB4 Support Its Proposed Function in Extending Healthy Longevity?

2025-11-21

Abstract excerpt

In 2015 a polymorphic variant of Bactericidal/permeability-increasing protein (BPI) Fold containing Family B Member 4 (BPIFB4) was genetically associated with longevity. Following on from this intriguing observation, a literature has developed that suggests that this poorly characterised secreted protein, plays a pleiotropic role in maintaining human health and extending lifespan. In this article we briefly review...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 4868c27f-5875-5d97-9540-18684725d395
DOI: 10.20944/preprints202511.1647.v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Does Localisation of BPIFB4 Support Its Proposed Function in Extending Healthy Longevity?DOI 10.20944/preprints202511.1647.v1Read

Does Localisation of BPIFB4 Support Its Proposed Function in Extending Healthy Longevity?Semantic proximity Read

Genetic Analysis Reveals a Longevity-Associated Protein Modulating Endothelial Function and Angiogenesis.Semantic proximity Read

The longevity-associated variant of BPIFB4 improves a CXCR4-mediated striatum-microglia crosstalk preventing disease progression in a mouse model of Huntington's disease.Semantic proximity Read

Distant cousins: genomic and sequence diversity within the BPI fold-containing (BPIF)/PLUNC protein family.Semantic proximity Read

Three Novel Genes Associated with Longevity Found in European BisonSemantic proximity Read

[P4-ATP-ase Atp8b1/FIC1: structural properties and (patho)physiological functions].Semantic proximity Read

The GIMAP Family Proteins: An Incomplete Puzzle.Semantic proximity Read

The longevity-associated BPIFB4 gene supports cardiac function and vascularization in ageing cardiomyopathy.Semantic proximity Read

PLUNC: A novel family of candidate host defence proteins expressed in the upper airways and nasopharynxSemantic proximity Read

A novel LPS-responsive beige-like anchor protein (LRBA) mutation presents with normal cytotoxic T lymphocyte-associated protein 4 (CTLA-4) and overactive TH17 immunity.Semantic proximity Read

The diabetes-prone BB rat carries a frameshift mutation in Ian4, a positional candidate of Iddm1.Semantic proximity Read

SCGB1D2 inhibits growth of Borrelia burgdorferi and affects susceptibility to Lyme diseaseSemantic proximity Read