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Article

Yes-associated protein (YAP) is a negative regulator of chondrogenesis in mesenchymal stem cells

29 May 2015

Abstract excerpt

INTRODUCTION: The control of differentiation of mesenchymal stromal/stem cells (MSCs) is crucial for tissue engineering strategies employing MSCs. The purpose of this study was to investigate whether the transcriptional co-factor Yes-associated protein (YAP) regulates chondrogenic differentiation of MSCs. METHODS: Expression of total YAP, its paralogue transcriptional co-activator with PDZ-binding motif (TAZ),...

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PMID: 26025096
DOI: 10.1186/s13075-015-0639-9

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Yes-associated protein (YAP) is a negative regulator of chondrogenesis in mesenchymal stem cellsPMID 26025096Read ↗

YAP maintains cartilage stem/progenitor cell homeostasis in osteoarthritisSemantic proximity Read ↗

YAP1 Is a Driver of Myofibroblast Differentiation in Normal and Diseased FibroblastsSemantic proximity Read ↗

Skeletal cell YAP and TAZ redundantly promote bone development by regulation of collagen I expression and organizationSemantic proximity Read ↗

YAP/TAZ upstream signals and downstream responses.Semantic proximity Read ↗

Yes-associated protein (yap) is required for early embryonic development in zebrafish (danio rerio).Semantic proximity Read ↗

Mechanosignaling through YAP and TAZ drives fibroblast activation and fibrosis.Semantic proximity Read ↗

Wnt/PCP-YAP-BIRC2 axis maintains cartilage stem/progenitor cell homeostasis in osteoarthritisSemantic proximity Read ↗

Extracellular signal-Regulated Kinase 5 (ERK5) is required for the Yes-associated protein (YAP) co-transcriptional activitySemantic proximity Read ↗

Shcbp1 deficiency dampens chondrocyte viability and cartilage ECM homeostasis via disturbing coordination of Akt and Erk signal pathwaysSemantic proximity Read ↗

A self-amplifying loop of YAP and SHH drives formation and expansion of heterotopic ossificationSemantic proximity Read ↗

The transcriptional coactivator YAP1 is overexpressed in osteoarthritis and promotes its progression by interacting with Beclin-1Semantic proximity Read ↗

YAP1 is essential for self-organized differentiation of pluripotent stem cellsSemantic proximity Read ↗

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