Article

YAP1 is essential for self-organized differentiation of pluripotent stem cells

2022-09-30

Abstract excerpt

The Yes-associated protein 1 (YAP1) is a downstream effector of the Hippo pathway and essential mechanotransducer. It has been suggested to play a crucial role for early embryo development, but the relevance for early germ layer commitment of human induced pluripotent stem cells (iPSCs) remains largely unclear. To gain better insight into the function of YAP1 in these early cell-fate decisions, we generated iPSC l...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: fdcb6559-8ac4-5f29-a55c-4932887c0fb7
DOI: 10.1101/2022.09.29.510043

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

YAP1 is essential for self-organized differentiation of pluripotent stem cellsDOI 10.1101/2022.09.29.510043Read

YAP1 and QSER1 are Key Modulators of Embryonic Signaling Pathways in the Mammalian EpiblastSemantic proximity Read

YAP1 Regulates the Self-organized Fate Patterning of hESCs-Derived GastruloidsSemantic proximity Read

Arp2/3 Complex Activity Enables Nuclear YAP for Naïve Pluripotency of Human Embryonic Stem CellsSemantic proximity Read

Yap controls stem/progenitor cell proliferation in the mouse postnatal epidermis.Semantic proximity Read

Oocyte-expressed yes-associated protein is a key activator of the early zygotic genome in mouseSemantic proximity Read

YAP1 Is a Driver of Myofibroblast Differentiation in Normal and Diseased FibroblastsSemantic proximity Read

Generation of a WWTR1 mutation induced pluripotent stem cell line, MUSIi012-A-1, using CRISPR/Cas9.Semantic proximity Read

YAP regulates porcine skin-derived stem cells self-renewal partly by repressing Wnt/β-catenin signaling pathwaySemantic proximity Read

Activin/nodal signalling controls the epigenome and epitranscriptome of human pluripotent stem cellsSemantic proximity Read

WT1 splice isoforms configure lineage bias during formative pluripotencySemantic proximity Read

Yes-associated protein (yap) is required for early embryonic development in zebrafish (danio rerio).Semantic proximity Read

Induction of Expandable Tissue-Specific Stem/Progenitor Cells through Transient Expression of YAP/TAZSemantic proximity Read