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Article

A self-amplifying loop of YAP and SHH drives formation and expansion of heterotopic ossification

23 Jun 2021

Abstract excerpt

in fibrodysplasia ossificans progressiva (FOP), another genetic HO, and nonhereditary HO mouse models. Genetic or pharmacological inhibition of YAP or SHH abolished HO in POH and FOP and acquired HO mouse models without affecting normal bone homeostasis, providing a previously unrecognized therapeutic rationale to prevent, reduce, and shrink HO.

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PMID: 34162750
DOI: 10.1126/scitranslmed.abb2233

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