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Article

YAP maintains cartilage stem/progenitor cell homeostasis in osteoarthritis

1 May 2024

Abstract excerpt

Background: The cartilage stem/progenitor cells (CSPC) play a critical role in maintaining cartilage homeostasis. However, the effects of phenotypic fluctuations of CSPC on cartilage degeneration and the role of CSPC in the pathogenesis of OA is largely unknown. Methods: . The OA rat model was established by Hulth's method. Lentivirus-mediated YAP (Lv-YAP) or lentivirus-mediated YAP RNAi (Lv-YAP-RNAi) was...

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PMID: 38817242
DOI: 10.1016/j.jot.2024.03.004

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