Characterization of functional methylomes by next-generation capture sequencing identifies novel disease-associated variants.

doi:10.1038/ncomms8211

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Article

Characterization of functional methylomes by next-generation capture sequencing identifies novel disease-associated variants.

Nature communications - 29 May 2015

Allum Fiona, Shao Xiaojian, Guénard Frédéric, Simon Marie-Michelle, Busche Stephan, Caron Maxime, Lambourne John, Lessard Julie, Tandre Karolina, Hedman Åsa K, Kwan Tony, Ge Bing, Rönnblom Lars, McCarthy Mark I, Deloukas Panos, Richmond Todd, Burgess Daniel, Spector Timothy D, Tchernof André, Marceau Simon, Lathrop Mark, Vohl Marie-Claude, Pastinen Tomi, Grundberg Elin

Abstract excerpt

Most genome-wide methylation studies (EWAS) of multifactorial disease traits use targeted arrays or enrichment methodologies preferentially covering CpG-dense regions, to characterize sufficiently large samples. To overcome this limitation, we present here a new customizable, cost-effective approach, methylC-capture sequencing (MCC-Seq), for sequencing functional methylomes, while simultaneously providing genetic...

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PMID: 26021296
DOI: 10.1038/ncomms8211
PMCID: PMC4544751

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