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Article

A genetic variation of the inflammatory cytokine interleukin-6 delays the initial onset and reduces the risk for sporadic Alzheimer's disease.

Annals of neurology - 1 May 1999

Papassotiropoulos A, Bagli M, Jessen F, Bayer T A, Maier W, Rao M L, Heun R

Abstract excerpt

Local inflammatory processes surrounding the amyloid plaques contribute to the progression and acceleration of the Alzheimer's disease (AD)-related neurodegeneration. Interleukin-6 (IL-6) is an inflammatory cytokine with possible involvement in the local immune response occurring in the central nervous system of AD patients. We tested the hypothesis as to whether a genetic polymorphism of the IL-6 gene (IL-6)...

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Identifiers

PMID: 10319892
DOI: 10.1002/1531-8249(199905)45:5<666::aid-ana18>3.0.co;2-3

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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