Article
Vascular factors and markers of inflammation in offspring with a parental history of late-onset Alzheimer disease.
Archives of general psychiatry - 1 Nov 2009
van Exel Eric, Eikelenboom Piet, Comijs Hannie, Frölich Marijke, Smit Johannes H, Stek Max L, Scheltens Philip, Eefsting Jan E, Westendorp Rudi G J
Abstract excerpt
CONTEXT: Alzheimer disease (AD) is a complex disorder with a strong heritable component. Amyloid pathology, vascular factors, and inflammation are postulated to be involved in its pathogenesis, but causality has not been established unequivocally. OBJECTIVE: To identify heritable traits in middle age that contribute to AD. DESIGN: We used a proven family design, comparing middle-aged offspring with and without a...
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