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Genetic Variants and Haplotypes of TOMM40, APOE, and APOC1 are Related to the Age of Onset of Late-onset Alzheimer Disease in a Colombian Population.

Alzheimer disease and associated disorders - 1 Jan 2000

Ortega-Rojas Jenny, Arboleda-Bustos Carlos E, Guerrero Esneyder, Neira Juan, Arboleda Humberto

Abstract excerpt

BACKGROUND: The Apolipoprotein E (APOE) gene is the main risk factor for late-onset Alzheimer disease (LOAD). Genetic variants and haplotypes in regions near the APOE locus may be associated with LOAD in the Colombian population. OBJECTIVE: We evaluated frequencies and risk of genetic variants and haplotypes in APOE, TOMM40, and APOC1 promoters, also in putative regulatory enhancer elements (TOMM40 IVS2-4 and...

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PMID: 35149606
DOI: 10.1097/WAD.0000000000000477

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