Article
Association between the TNFalpha-308 A/G polymorphism and the onset-age of Alzheimer disease.
American journal of medical genetics - 8 Jul 2002
Alvarez Victoria, Mata Ignacio F, González Pelayo, Lahoz Carlos H, Martínez Carmen, Peña Joaquín, Guisasola Luis M, Coto Eliecer
Abstract excerpt
Local inflammatory processes associated with amyloid plaques would contribute to the progression of late-onset Alzheimer disease (LOAD). Tumor necrosis factors alpha (TNF(alpha)) and beta (LT(alpha)) are inflammatory cytokines involved in the local immune response occurring in the central nervous system of LOAD patients. Genetic variation at these genes could contribute to the risk of developing AD or influence...
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