Article
Analysis of variations in the tryptophan hydroxylase-2 (TPH2) gene in cocaine dependence.
Addiction biology - 1 Mar 2006
Dahl John P, Cubells Joseph F, Ray Riju, Weller Andrew E, Lohoff Falk W, Ferraro Thomas N, Oslin David W, Kampman Kyle M, Dackis Charles, Tang Yilang, Gelernter Joel, Kranzler Henry R, O'Brien Charles P, Berrettini Wade H
Abstract excerpt
While the exact physiological mechanisms underlying cocaine dependence remain unclear, a growing body of evidence indicates a role for the serotonergic neurotransmitter system in the pathology of this substance use disorder. The focus of the present study is to determine whether genetic variation in the tryptophan hydroxylase-2 (TPH2) gene, which encodes the enzyme responsible for synthesis of the majority of the...
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