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Article

Comprehensive assessment of genetic sequence variants in the antioxidant 'master regulator' NRF2 in idiopathic Parkinson's disease.

PloS one - 1 Jan 2015

Todorovic Michael, Newman Jeremy R B, Shan Jianguo, Bentley Steven, Wood Stephen A, Silburn Peter A, Mellick George D

Abstract excerpt

Parkinson's disease (PD) is a complex neurodegenerative disorder influenced by a combination of genetic and environmental factors. The molecular mechanisms that underlie PD are unknown; however, oxidative stress and impairment of antioxidant defence mechanisms have been implicated as major contributors to disease pathogenesis. Previously, we have reported a PD patient-derived cellular model generated from...

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Identifiers

PMID: 26010367
DOI: 10.1371/journal.pone.0128030
PMCID: PMC4444110

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