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Article

NFE2L2, PPARGC1α, and pesticides and Parkinson's disease risk and progression.

Mechanisms of ageing and development - 1 Jul 2018

Paul Kimberly C, Sinsheimer Janet S, Cockburn Myles, Bronstein Jeff M, Bordelon Yvette, Ritz Beate

Abstract excerpt

OBJECTIVE: To investigate three expression-altering NFE2L2 SNPs and four PPARGC1α previously implicated SNPs and pesticides on Parkinson's disease (PD) risk and symptom progression. METHODS: In 472 PD patients and 532 population-based controls, we examined variants and their interactions with maneb and paraquat (MB/PQ) pesticide exposure on PD onset (logistic regression) and progression of motor symptoms and...

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Identifiers

PMID: 29630901
DOI: 10.1016/j.mad.2018.04.004
PMCID: PMC5994195

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