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Article

Genetic risk for Parkinson's disease correlates with alterations in neuronal manganese sensitivity between two human subjects.

Neurotoxicology - 1 Dec 2012

Aboud Asad A, Tidball Andrew M, Kumar Kevin K, Neely M Diana, Ess Kevin C, Erikson Keith M, Bowman Aaron B

Abstract excerpt

Manganese (Mn) is an environmental risk factor for Parkinson's disease (PD). Recessive inheritance of PARK2 mutations is strongly associated with early onset PD (EOPD). It is widely assumed that the influence of PD environmental risk factors may be enhanced by the presence of PD genetic risk factors in the genetic background of individuals. However, such interactions may be difficult to predict owing to the...

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Identifiers

PMID: 23099318
DOI: 10.1016/j.neuro.2012.10.009
PMCID: PMC3518601

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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