Article
Genetic analysis of NFE2L2 promoter variation in Taiwanese Parkinson's disease.
Parkinsonism & related disorders - 1 Feb 2013
Chen Yi-Chun, Wu Yih-Ru, Wu Yi-Ci, Lee-Chen Guey-Jen, Chen Chiung-Mei
Abstract excerpt
Oxidative stress has been reported as one of the pathogeneses of Parkinson's disease (PD). Nuclear factor erythroid 2-related factor 2 (Nrf2) is a transcription factor that regulates the expression of the target genes involved in antioxidant pathway. The promoter polymorphisms of the Nrf2-encoding gene, NFE2L2, have been shown to affect the promoter activity. Inconsistent findings of the associations between...
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