Article
Single nucleotide polymorphism-based genome-wide chromosome copy change, loss of heterozygosity, and aneuploidy in Barrett's esophagus neoplastic progression.
Cancer prevention research (Philadelphia, Pa.) - 1 Nov 2008
Li Xiaohong, Galipeau Patricia C, Sanchez Carissa A, Blount Patricia L, Maley Carlo C, Arnaudo Jessica, Peiffer Daniel A, Pokholok Dmitry, Gunderson Kevin L, Reid Brian J
Abstract excerpt
Chromosome copy gain, loss, and loss of heterozygosity (LOH) involving most chromosomes have been reported in many cancers; however, less is known about chromosome instability in premalignant conditions. 17p LOH and DNA content abnormalities have been previously reported to predict progression from Barrett's esophagus (BE) to esophageal adenocarcinoma (EA). Here, we evaluated genome-wide chromosomal instability...
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