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Article

Assessment of mutational load in biopsy tissue provides additional information about genomic instability to histological classifications of Barrett's esophagus.

Journal of gastrointestinal cancer - 1 Jun 2014

Khara Harshit S, Jackson Sara A, Nair Saraswathi, Deftereos Georgios, Patel Shweta, Silverman Jan F, Ellsworth Eric, Sumner Cameron, Corcoran Brendan, Smith Dennis M, Finkelstein Sydney, Gross Seth A

Abstract excerpt

PURPOSE: Progression of Barrett's esophagus (BE) to esophageal adenocarcinoma (EAC) is associated with accumulated genomic instability. Current risk stratification of BE for EAC relies on histological classification and grade of dysplasia. However, histology alone cannot assess the risk of patients with inconsistent or non-dysplastic BE histology. We, therefore, examined the presence and extent of genomic...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 24402860
DOI: 10.1007/s12029-013-9570-y
PMCID: PMC4024388

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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