Article
Molecular basis for differential modulation of BK channel voltage-dependent gating by auxiliary γ subunits.
The Journal of general physiology - 1 Jun 2015
Li Qin, Fan Fei, Kwak Ha Rim, Yan Jiusheng
Abstract excerpt
Large conductance Ca(2+)- and voltage-activated potassium (BK) channels are comprised of pore-forming α subunits and various regulatory auxiliary subunits. The BK channel auxiliary γ (BKγ) subunits are a newly identified class of proteins containing an extracellular leucine-rich repeat domain (LRRD), a single transmembrane (TM) segment, and a short cytoplasmic C-terminal tail (C-tail). Although each of the four...
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