Article
Defining the BK channel domains required for beta1-subunit modulation.
Proceedings of the National Academy of Sciences of the United States of America - 28 Mar 2006
Morrow John P, Zakharov Sergey I, Liu Guoxia, Yang Lin, Sok Andrea J, Marx Steven O
Abstract excerpt
In a wide variety of cell types, including neurons and smooth muscle cells, activation of the large-conductance voltage- and Ca(2+)-activated K(+) (BK) channels causes transient membrane hyperpolarization, thereby regulating cellular excitability. Similar to other voltage-gated ion channels, BK channels, a tetramer of alpha-subunits, associate with auxiliary beta-subunits in a tissue-specific manner, modifying...
Topics
- Amino Acid Sequence
- Animals
- Cell Line
- Electrophysiology
- Estradiol
- Humans
- Ion Channel Gating
- Kinetics
- Mice
- Molecular Sequence Data
- Mutation
- Patch-Clamp Techniques
- Potassium Channels, Calcium-Activated
- Protein Binding