Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Membrane-associated guanylate kinase-like properties of beta-subunits required for modulation of voltage-dependent Ca2+ channels.

Proceedings of the National Academy of Sciences of the United States of America - 4 May 2004

Takahashi Shoji X, Miriyala Jayalakshmi, Colecraft Henry M

Abstract excerpt

High-voltage-activated Ca2+ channels regulate diverse functions ranging from muscle contraction to synaptic transmission. Association between auxiliary beta- and distinct pore-forming alpha1-subunits is obligatory for forming functional high-voltage-activated Ca2+ channels, yet the structural determinants underlying this interaction remain poorly understood. Recently, homology modeling of Ca(2+)-channel...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Amino Acid Motifs
Share to Calcium Channels

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Guanylate Kinases

Share to Mutation

Share to Protein Structure, Tertiary

Share to Structure-Activity Relationship

Source

Open in PubMed Open full text

Identifiers

PMID: 15100405
DOI: 10.1073/pnas.0306665101
PMCID: PMC406488

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Membrane-associated guanylate kinase-like properties of beta-subunits required for modulation of voltage-dependent Ca2+ channels.PMID 15100405Read ↗

Calcium channel function regulated by the SH3-GK module in beta subunits.Semantic proximity Read ↗

A CaVbeta SH3/guanylate kinase domain interaction regulates multiple properties of voltage-gated Ca2+ channels.Semantic proximity Read ↗

Homodimerization of the Src homology 3 domain of the calcium channel β-subunit drives dynamin-dependent endocytosis.Semantic proximity Read ↗

The guanylate kinase domain of the beta-subunit of voltage-gated calcium channels suffices to modulate gating.Semantic proximity Read ↗

Molecular basis for differential modulation of BK channel voltage-dependent gating by auxiliary γ subunits.Semantic proximity Read ↗

Sodium channel β subunits: emerging targets in channelopathies.Semantic proximity Read ↗

Defining the BK channel domains required for beta1-subunit modulation.Semantic proximity Read ↗

Electrophysiology and beyond: multiple roles of Na+ channel β subunits in development and disease.Semantic proximity Read ↗

Several structural domains contribute to the regulation of N-type calcium channel inactivation by the beta 3 subunit.Semantic proximity Read ↗

MaxiK channel partners: physiological impact.Semantic proximity Read ↗

Critical determinants of the G protein gamma subunits in the Gbetagamma stimulation of G protein-activated inwardly rectifying potassium (GIRK) channel activity.Semantic proximity Read ↗

Auxiliary subunits: essential components of the voltage-gated calcium channel complex.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.