Article
Structural basis of gating modulation of Kv4 channel complexes.
Nature - 1 Nov 2021
Kise Yoshiaki, Kasuya Go, Okamoto Hiroyuki H, Yamanouchi Daichi, Kobayashi Kan, Kusakizako Tsukasa, Nishizawa Tomohiro, Nakajo Koichi, Nureki Osamu
Abstract excerpt
Modulation of voltage-gated potassium (Kv) channels by auxiliary subunits is central to the physiological function of channels in the brain and heart1,2. Native Kv4 tetrameric channels form macromolecular ternary complexes with two auxiliary β-subunits-intracellular Kv channel-interacting proteins (KChIPs) and transmembrane dipeptidyl peptidase-related proteins (DPPs)-to evoke rapidly activating and inactivating...
Topics
- Animals
- Cryoelectron Microscopy
- Dipeptidyl-Peptidases and Tripeptidyl-Peptidases
- Female
- Humans
- Ion Channel Gating
- Kv Channel-Interacting Proteins
- Models, Molecular
- Multiprotein Complexes
- Mutation
- Nerve Tissue Proteins
- Oocytes
- Potassium Channels