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Article

Relationship between auxiliary gamma subunits and mallotoxin on BK channel modulation.

Scientific reports - 6 Feb 2017

Guan Xin, Li Qin, Yan Jiusheng

Abstract excerpt

The large-conductance, calcium- and voltage-activated K+(BK) channel consists of the pore-forming α subunits (BKα) and auxiliary subunits. The auxiliary γ1-3 subunits potently modulate the BK channel by shifting its voltage-dependence of channel activation toward the hyperpolarizing direction by approximately 145 mV (γ1), 100 mV (γ2), and 50 mV (γ3). Mallotoxin is a potent small-molecule BK channel activator. We...

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Identifiers

PMID: 28165042
DOI: 10.1038/srep42240
PMCID: PMC5292707

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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