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Article

Interaction of G protein beta subunit with inward rectifier K(+) channel Kir3.

Molecular pharmacology - 1 Nov 2003

Zhao Qi, Kawano Takeharu, Nakata Hiroko, Nakajima Yasuko, Nakajima Shigehiro, Kozasa Tohru

Abstract excerpt

G protein betagamma subunits bind and activate G protein-coupled inward rectifier K+ (GIRK) channels. This protein-protein interaction is crucial for slow hyperpolarizations of cardiac myocytes and neurons. The crystal structure of Gbeta shows a seven-bladed propeller with four beta strands in each blade. The Gbeta/Galpha interacting surface contains sites for activating GIRK channels. Furthermore, our recent...

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Identifiers

PMID: 14573757
DOI: 10.1124/mol.64.5.1085

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Interaction of G protein beta subunit with inward rectifier K(+) channel Kir3.PMID 14573757Read ↗

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