Article
Gating control of the cardiac sodium channel Nav1.5 by its β3-subunit involves distinct roles for a transmembrane glutamic acid and the extracellular domain.
The Journal of biological chemistry - 20 Dec 2019
Salvage Samantha C, Zhu Wandi, Habib Zaki F, Hwang Soyon S, Irons Jennifer R, Huang Christopher L H, Silva Jonathan R, Jackson Antony P
Abstract excerpt
The auxiliary β3-subunit is an important functional regulator of the cardiac sodium channel Nav1.5, and some β3 mutations predispose individuals to cardiac arrhythmias. The β3-subunit uses its transmembrane α-helix and extracellular domain to bind to Nav1.5. Here, we investigated the role of an unusually located and highly conserved glutamic acid (Glu-176) within the β3 transmembrane region and its potential for...
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