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Article

Synthesis and antimicrobial activity of chloramphenicol-polyamine conjugates.

Bioorganic & medicinal chemistry - 1 Jul 2015

Magoulas George E, Kostopoulou Ourania N, Garnelis Thomas, Athanassopoulos Constantinos M, Kournoutou Georgia G, Leotsinidis Michael, Dinos George P, Papaioannou Dionissios, Kalpaxis Dimitrios L

Abstract excerpt

A series of chloramphenicol (CAM) amides with polyamines (PAs), suitable for structure-activity relationship studies, were synthesized either by direct attachment of the PA chain on the 2-aminopropane-1,3-diol backbone of CAM, previously oxidized selectively at its primary hydroxyl group, or from chloramphenicol base (CLB) through acylation with succinic or phthalic anhydride and finally coupling with a PA....

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Identifiers

PMID: 26001343
DOI: 10.1016/j.bmc.2015.04.069

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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