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Article

Synthesis and biological evaluation of dihydromotuporamine derivatives in cells containing active polyamine transporters.

Journal of medicinal chemistry - 2 Jun 2005

Kaur Navneet, Delcros Jean-Guy, Martin Bénédicte, Phanstiel Otto

Abstract excerpt

Dihydromotuporamine C (4) and its 4,4-triamine analogue (5) were synthesized in good yield using ring-closing metathesis (RCM) methods. Comparison of their biological activities (Ki determinations in L1210 cells and IC50 determinations in L1210, CHO, and CHO-MG cells) revealed that the motuporami...

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PMID: 15916435
DOI: 10.1021/jm0491288

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-15916435-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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