Article

Inhibition of Enzymatic Acetylation-Mediated Resistance to Plazomicin by Silver Ions

2023-01-06

Abstract excerpt

Plazomicin is a recently U.S. Food and Drug Administration (FDA)-approved semisynthetic aminoglycoside. Its structure consists of a sisomicin scaffold modified by adding a 2(S)-hydroxy aminobutyryl group at the N1 position and a hydroxyethyl substituent at the 6′ position. These substitutions produced a molecule refractory to most aminoglycoside-modifying enzymes. The main enzyme within this group that recog...

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Literature Corpus work: 4eb69ed1-8f18-53e8-8a68-e806641f5edb
DOI: 10.20944/preprints202301.0110.v1

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