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Article

A comparison of chloroambucil- and xylene-containing polyamines leads to improved ligands for accessing the polyamine transport system.

Journal of medicinal chemistry - 13 Mar 2008

Kaur Navneet, Delcros Jean-Guy, Imran Jon, Khaled Annette, Chehtane Mounir, Tschammer Nuska, Martin Bénédicte, Phanstiel Otto

Abstract excerpt

Several disubstituted arylene- and chloroambucil-polyamine conjugates were synthesized and evaluated for their ability to target cells via their polyamine transport system (PAT). As compared to the monosubstituted analogues, the disubstituted arylene systems were superior PAT targeting agents. Using a Chinese hamster ovary (CHO) cell line (PAT active) and its CHO-MG mutant (PAT inactive), the series was screened...

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Identifiers

PMID: 18281932
DOI: 10.1021/jm070794t

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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