Article

Clincelin: A redesigned lincosamide with enhanced intracellular accumulation and adaptive binding to resistant ribosomes

2026-02-25

Abstract excerpt

<title>Abstract</title> Lincosamides are an important class of clinically used antibiotics that inhibit translation by binding to the peptidyl transferase center of the ribosome. However, their efficacy is impaired by the widespread acquisition of genes coding for erythromycin resistance methyltransferase (Erm), which confer resistance by dimethylating adenine A2058 in the 23S ribosomal RNA. Here, we report...

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Literature Corpus work: 9c0db890-c80e-5718-8b85-ce67c163af68
DOI: 10.21203/rs.3.rs-8873829/v1

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