Article
Aquaporin-4 gene variant independently associated with oedema after intracerebral haemorrhage.
Neurological research - 1 Aug 2015
Appelboom Geoff, Bruce Sam, Duren Andrew, Piazza Matt, Monahan Aimee, Christophe Brandon, Zoller Steve, LoPresti Melissa, Connolly E Sander
Abstract excerpt
INTRODUCTION: Aquaporin-4 (AQP4) is the prominent water-channel protein in the brain playing a critical role in controlling cell water content. After intracerebral haemorrhage (ICH), perihematomal oedema (PHE) formation leads to a rapid increase in intracranial pressure (ICP) after the initial bleed. We sought to investigate the effect of a common genomic variant in the AQP4 gene on PHE formation after ICH....
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