Article
Is the brain water channel aquaporin-4 a pathogenetic factor in idiopathic intracranial hypertension? Results from a combined clinical and genetic study in a Norwegian cohort.
Acta ophthalmologica - 1 Feb 2013
Kerty Emilia, Heuser Kjell, Indahl Ulf G, Berg Paul R, Nakken Sigve, Lien Sigbjørn, Omholt Stig W, Ottersen Ole P, Nagelhus Erlend A
Abstract excerpt
PURPOSE: Idiopathic intracranial hypertension (IIH) is a condition of increased intracranial pressure of unknown aetiology. Patients with IIH usually suffer from headache and visual disturbances. High intracranial pressure despite normal ventricle size and negative MRI indicate perturbed water flux across cellular membranes, which is provided by the brain water channel aquaporin-4 (AQP4). IIH could be associated...
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