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Article

Regionally clustered ABCC8 polymorphisms in a prospective cohort predict cerebral oedema and outcome in severe traumatic brain injury.

Journal of neurology, neurosurgery, and psychiatry - 1 Nov 2018

Jha Ruchira Menka, Koleck Theresa A, Puccio Ava M, Okonkwo David O, Park Seo-Young, Zusman Benjamin E, Clark Robert S B, Shutter Lori A, Wallisch Jessica S, Empey Philip E, Kochanek Patrick M, Conley Yvette P

Abstract excerpt

OBJECTIVE: ABCC8 encodes sulfonylurea receptor 1, a key regulatory protein of cerebral oedema in many neurological disorders including traumatic brain injury (TBI). Sulfonylurea-receptor-1 inhibition has been promising in ameliorating cerebral oedema in clinical trials. We evaluated whether ABCC8 tag single-nucleotide polymorphisms predicted oedema and outcome in TBI. METHODS: DNA was extracted from 485...

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Identifiers

PMID: 29674479
DOI: 10.1136/jnnp-2017-317741
PMCID: PMC6181785

Genes

ABCC8

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