Article
Burden of risk alleles for hypertension increases risk of intracerebral hemorrhage.
Stroke - 1 Nov 2012
Falcone Guido J, Biffi Alessandro, Devan William J, Jagiella Jeremiasz M, Schmidt Helena, Kissela Brett, Hansen Björn M, Jimenez-Conde Jordi, Giralt-Steinhauer Eva, Elosua Roberto, Cuadrado-Godia Elisa, Soriano Carolina, Ayres Alison M, Schwab Kristin, Pera Joanna, Urbanik Andrzej, Rost Natalia S, Goldstein Joshua N, Viswanathan Anand, Pichler Alexander, Enzinger Christian, Norrving Bo, Tirschwell David L, Selim Magdy, Brown Devin L, Silliman Scott L, Worrall Bradford B, Meschia James F, Kidwell Chelsea S, Montaner Joan, Fernandez-Cadenas Israel, Delgado Pilar, Broderick Joseph P, Greenberg Steven M, Roquer Jaume, Lindgren Arne, Slowik Agnieszka, Schmidt Reinhold, Flaherty Matthew L, Kleindorfer Dawn O, Langefeld Carl D, Woo Daniel, Rosand Jonathan
Abstract excerpt
BACKGROUND AND PURPOSE: Genetic variation influences risk of intracerebral hemorrhage (ICH). Hypertension (HTN) is a potent risk factor for ICH and several common genetic variants (single nucleotide polymorphisms [SNPs]) associated with blood pressure levels have been identified. We sought to determine whether the cumulative burden of blood pressure-related SNPs is associated with risk of ICH and pre-ICH...
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