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Article

Apolipoprotein E-ε4 allele is associated with perihematomal brain edema and poor outcomes in patients with intracerebral hemorrhage.

Scientific reports - 16 Feb 2025

Huang Lei, Wu Qian, Ye Fei, Che Wei, Zhao Xu, Yang ChaoZhen, Ren Siying, Wu Guofeng, Wang Likun

Abstract excerpt

Intracerebral hemorrhage (ICH) poses significant disability and mortality risks and perihematomal edema (PHE) plays a crucial role in ICH prognosis. The ApoE-ε4 allele has been implicated in exacerbating PHE and influencing neurological recovery post-ICH, yet, this specific association has not been explored much. This study aimed to investigate the correlation between ApoE-ε4 allele, PHE, and clinical prognosis...

Read the complete abstract on PubMed

Topics

Humans
Male
Female
Brain Edema
Middle Aged
Cerebral Hemorrhage
Alleles

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Apolipoprotein E4

Prognosis

Aged

Prospective Studies

Source

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Identifiers

PMID: 39956815
DOI: 10.1038/s41598-025-89868-3
PMCID: PMC11830776

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