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Article

Rapid molecular evolution across amniotes of the IIS/TOR network.

Proceedings of the National Academy of Sciences of the United States of America - 2 Jun 2015

McGaugh Suzanne E, Bronikowski Anne M, Kuo Chih-Horng, Reding Dawn M, Addis Elizabeth A, Flagel Lex E, Janzen Fredric J, Schwartz Tonia S

Abstract excerpt

The insulin/insulin-like signaling and target of rapamycin (IIS/TOR) network regulates lifespan and reproduction, as well as metabolic diseases, cancer, and aging. Despite its vital role in health, comparative analyses of IIS/TOR have been limited to invertebrates and mammals. We conducted an extensive evolutionary analysis of the IIS/TOR network across 66 amniotes with 18 newly generated transcriptomes from...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 25991861
DOI: 10.1073/pnas.1419659112
PMCID: PMC4460498

Genes

IGF1
IGF2
INSR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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