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Article

Phylogeny of the insulin‐like growth factors (IGFS) and receptors: A molecular approach

1 Aug 1993

Abstract excerpt

The IGFs (IGF-I and IGF-II) are essential for normal mammalian growth and development. Their actions are mediated primarily by their interactions with the type I IGF receptor (IGF-I receptor), a transmembrane tyrosine kinase. The ligands and the IGF-I receptor are structurally related to insulin and to the insulin receptor, respectively. Analysis of evolutionary conservation has often provided insights into...

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PMID: 8398110
DOI: 10.1002/mrd.1080350403

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Source receipt: pubmed, retrieved 7 Sept 2026.

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