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Evolution of the vertebrate insulin receptor substrate (Irs) gene family

23 Jun 2017

Abstract excerpt

BACKGROUND: Insulin receptor substrate (Irs) proteins are essential for insulin signaling as they allow downstream effectors to dock with, and be activated by, the insulin receptor. A family of four Irs proteins have been identified in mice, however the gene for one of these, IRS3, has been pseudogenized in humans. While it is known that the Irs gene family originated in vertebrates, it is not known when it...

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PMID: 28645244
DOI: 10.1186/s12862-017-0994-z

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