Evolution of Ancient Functions in the Vertebrate Insulin-Like Growth Factor System Uncovered by Study of Duplicated Salmonid Fish Genomes

Abstract excerpt

Whole-genome duplication (WGD) was experienced twice by the vertebrate ancestor (2 rounds; 2R), again by the teleost fish ancestor (3R) and most recently in certain teleost lineages (4R). Consequently, vertebrate gene families are often expanded in 3R and 4R genomes. Arguably, many types of "functional divergence" present across 2R gene families will exceed that between 3R/4R paralogs of genes comprising 2R...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to FOXO transcription factor regulation
• Share to Growth Hormone and Insulin-like Growth Factors
• Share to Pancreatic function and diabetes