Article
Evolution of the insulin receptor family and receptor isoform expression in vertebrates.
Molecular biology and evolution - 1 Jun 2008
Hernández-Sánchez Catalina, Mansilla Alicia, de Pablo Flora, Zardoya Rafael
Abstract excerpt
The molecular phylogeny of the vertebrate insulin receptor (IR) family was reconstructed under maximum likelihood (ML) to establish homologous relationships among its members. A sister group relationship between the orphan insulin-related receptor (IRR) and the insulin-like growth factor 1 receptor (IGF1R) to the exclusion of the IR obtained maximal bootstrap support. Although both IR and IGF1R were identified in...
Topics
- Alternative Splicing
- Amino Acid Sequence
- Animals
- Chick Embryo
- Conserved Sequence
- Evolution, Molecular
- Exons
- Genetic Variation
- Mice
- Molecular Sequence Data
- Multigene Family
- Phylogeny
- Protein Isoforms
- Protein Structure, Quaternary
- Receptor, IGF Type 1
- Receptor, Insulin