Article
Network-level molecular evolutionary analysis of the insulin/TOR signal transduction pathway across 12 Drosophila genomes.
Genome research - 1 Feb 2009
Alvarez-Ponce David, Aguadé Montserrat, Rozas Julio
Abstract excerpt
Biological function is based on complex networks consisting of large numbers of interacting molecules. The evolutionary properties of molecular networks and, in particular, the impact of network architecture on the sequence evolution of its individual components are, nonetheless, still poorly understood. Here, we conducted a fine-scale network-level molecular evolutionary analysis of the insulin/TOR pathway...
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