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Article

PTEN loss is associated with follicular variant of Middle Eastern papillary thyroid carcinoma.

British journal of cancer - 9 Jun 2015

Beg S, Siraj A K, Jehan Z, Prabakaran S, Al-Sobhi S S, Al-Dawish M, Al-Dayel F, Al-Kuraya K S

Abstract excerpt

BACKGROUND: PTEN gene at chromosomes 10q23.3 is a tumour suppressor gene that is inactivated in many types of human cancers. The known mechanisms of PTEN inactivation are rendered to mutation, epigenetic silencing by aberrant methylation or gene deletion. Although PTEN role has been documented in many cancers, PTEN alteration in papillary thyroid carcinoma (PTC) has not been fully elucidated. The aim of this...

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Share to Carcinoma
Share to Carcinoma, Papillary
Share to In Situ Hybridization, Fluorescence

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Open in PubMed Open full text

Identifiers

PMID: 25989274
DOI: 10.1038/bjc.2015.169
PMCID: PMC4580399

Genes

PTEN

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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PTEN loss is associated with follicular variant of Middle Eastern papillary thyroid carcinoma.PMID 25989274Read ↗

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