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Article

PTEN mutations and activation of the PI3K/Akt/mTOR signaling pathway in papillary tumors of the pineal region.

Journal of neuropathology and experimental neurology - 1 Aug 2014

Goschzik Tobias, Gessi Marco, Denkhaus Dorota, Pietsch Torsten

Abstract excerpt

Papillary tumors of the pineal region (PTPR) are recognized as a distinct entity in the World Health Organization classification of CNS tumors. Papillary tumors of the pineal region frequently show loss of chromosome 10, but no studies have investigated possible target genes on this chromosome. Chromosome 10 harbors the PTEN (phosphatase and tensin homolog) gene, the inactivation of which, by mutation or...

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Source

Identifiers

PMID: 25003235
DOI: 10.1097/NEN.0000000000000093

Genes

PTEN
MIP

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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