Article
Somatic mutation and germline variants of MINPP1, a phosphatase gene located in proximity to PTEN on 10q23.3, in follicular thyroid carcinomas.
The Journal of clinical endocrinology and metabolism - 1 Apr 2001
Gimm O, Chi H, Dahia P L, Perren A, Hinze R, Komminoth P, Dralle H, Reynolds P R, Eng C
Abstract excerpt
Various genes have been identified to play a role in the pathogenesis of follicular thyroid tumors. Cowden syndrome is the only known familial syndrome with an increased risk of both follicular thyroid adenoma (FA) and carcinoma (FTC). Germline mutations in the tumor suppressor gene PTEN, which encodes a dual-specificity phosphatase, have been found in up to 80% of patients with Cowden syndrome suggesting a role...
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