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Article

Loss of PTEN is associated with elevated EGFR and HER2 expression and worse prognosis in salivary gland cancer

12 Jan 2012

Abstract excerpt

BACKGROUND: Activity of the tumour-suppressor gene PTEN is reduced in different types of cancer and implicates non-responsiveness to targeted therapy. This study evaluates the gene and protein status of PTEN in salivary gland carcinomas. METHODS: A total of 287 carcinomas of the major and minor salivary glands were investigated for phosphatase and tensin homologue located on chromosome 10 (PTEN) deletion and loss...

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Share to PI3K/AKT/mTOR signaling in cancer
Share to Salivary Gland Disorders and Functions
Share to Salivary Gland Tumors Diagnosis and Treatment

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 22240798
DOI: 10.1038/bjc.2011.605

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Loss of PTEN is associated with elevated EGFR and HER2 expression and worse prognosis in salivary gland cancerPMID 22240798Read ↗

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