Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Comprehensive analysis of PTEN status in breast carcinomas.

International journal of cancer - 15 Jul 2013

Jones Natalie, Bonnet Françoise, Sfar Sana, Lafitte Marie, Lafon Delfine, Sierankowski Ghislaine, Brouste Véronique, Banneau Guillaume, Tunon de Lara Christine, Debled Marc, MacGrogan Gaëtan, Longy Michel, Sevenet Nicolas

Abstract excerpt

PTEN plays a well-established role in the negative regulation of the PI3K pathway, which is frequently activated in several cancer types, including breast cancer. A nuclear function in the maintenance of chromosomal stability has been proposed for PTEN but is yet to be clearly defined. In order to improve understanding of the role of PTEN in mammary tumorigenesis in terms of a possible gene dosage effect, its...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Carcinoma, Ductal, Breast
Share to Chromosomal Instability

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Chromosomes

Share to Class I Phosphatidylinositol 3-Kinases

Share to Lymph Nodes

Share to PTEN Phosphohydrolase

Share to Receptor, ErbB-2

Share to Receptors, Estrogen

Source

Identifiers

PMID: 23319441
DOI: 10.1002/ijc.28021

Genes

PTEN

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Comprehensive analysis of PTEN status in breast carcinomas.PMID 23319441Read ↗

Partial PTEN deletion is linked to poor prognosis in breast cancerSemantic proximity Read ↗

PTEN Genetic and Epigenetic Alterations Define Distinct Subgroups in North Indian Breast Cancer PatientsSemantic proximity Read ↗

PIK3CA mutations correlate with hormone receptors, node metastasis, and ERBB2, and are mutually exclusive with PTEN loss in human breast carcinoma.Semantic proximity Read ↗

Dysregulated PTEN-PKB and negative receptor status in human breast cancer.Semantic proximity Read ↗

Pan-cancer genomic analysis shows hemizygous PTEN loss tumors are associated with immune evasion and poor outcomeSemantic proximity Read ↗

Pan-cancer genomic analysis shows hemizygous <i>PTEN</i> loss tumors are associated with immune evasion and poor outcomeSemantic proximity Read ↗

Prognostic and Predictive Implications of PTEN in Breast Cancer: Unfulfilled Promises but Intriguing PerspectivesSemantic proximity Read ↗

PTEN: Multiple Functions in Human Malignant TumorsSemantic proximity Read ↗

Frequent PTEN genomic alterations and activated phosphatidylinositol 3-kinase pathway in basal-like breast cancer cellsSemantic proximity Read ↗

Reduced expression of PTEN correlates with breast cancer progression.Semantic proximity Read ↗

Genomic Rearrangements of PTEN in Prostate CancerSemantic proximity Read ↗

Tumor suppressor PTEN in breast cancer: heterozygosity, mutations and protein expression.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.